A new study from the University of Cambridge offers renewed hope for patients living with chronic lymphocytic leukemia (CLL), the most common form of adult leukemia. Researchers have found that even modest, low-impact exercise can significantly ease fatigue and improve the quality of life in patients—particularly those not undergoing active treatment.
The findings, which add to a growing body of evidence connecting physical activity to better cancer outcomes, are especially significant for individuals with slow-progressing blood cancers who often face long periods of symptom management rather than curative interventions.
A Watchful Diagnosis With Lingering Symptoms
CLL is a slow-growing cancer of the blood and bone marrow that primarily affects older adults, with a majority of cases diagnosed in individuals over the age of 70. Due to its indolent nature, many patients are placed under “active monitoring,” where treatment is deferred until the disease shows signs of progression.
But this watch-and-wait approach can take a toll. Patients—even those not undergoing chemotherapy—often experience chronic fatigue, anxiety, and vulnerability to infections. For those who do receive treatment, side effects such as nausea, bleeding, diarrhea, and immune suppression can further affect daily life.
“It’s a quiet disease, but a heavy one,” said one of the lead researchers, reflecting on the long, emotionally taxing course that many patients face.
12 Weeks, Meaningful Results
In the pilot study, participants with CLL engaged in 12 weeks of guided, low-intensity exercise—including walking, yoga, and swimming. The outcomes were clear: reduced cancer-related fatigue, enhanced mobility, and improved physical and emotional well-being.
For those on active monitoring, the researchers also noted improved immune function and a potential slowing in the growth of cancerous B-cells.
“What surprised us most,” researchers noted, “was how impactful even light activity was for these patients—especially those who were previously inactive.”
Exercise for Blood Cancers: A Growing Frontier
While the benefits of exercise are well-established for patients with solid tumors like breast or colon cancer, similar studies on blood cancers have been relatively limited. This research is among the first to examine the direct benefits of structured exercise programs in patients with CLL.
Notably, patients who began the program with lower fitness levels or more severe symptoms experienced the greatest gains—suggesting that even the most vulnerable groups can benefit.
For patients undergoing active treatment, the benefits were similar, reinforcing the idea that physical activity can serve as an adjunct therapy during or after medical intervention.
Practical Recommendations for Patients
Health agencies recommend 150 to 300 minutes of moderate-intensity activity per week—such as walking or cycling—or 75 to 150 minutes of vigorous activity. Strength training twice a week is also advised.
For immunocompromised patients, researchers suggest using less crowded outdoor spaces, wearing masks in public gyms, or exercising at home to minimize infection risks.
“Precaution is important, but inactivity is far riskier,” said the study authors, emphasizing that movement—however small—is better than none.
Beyond Treatment: A Path to Empowerment
The study concludes with a powerful message: living with CLL does not mean surrendering to fatigue or fear. For patients who feel caught between diagnosis and delayed treatment, gentle exercise offers a path to agency, resilience, and improved daily life.
“Physical activity isn’t just good for the body—it restores a sense of control in the face of uncertainty,” said one participant.
As cancer care evolves beyond medicine and into holistic health strategies, movement may emerge as one of the most accessible and impactful tools for long-term survival and well-being.
